AI Assistant Startups funded by Y Combinator (YC) 2026

ScienceSwarm makes AI useful for what matters. Coding assistants turned millions of people into software developers — we're doing the same for science. Our platform lets anyone point their AI at unsolved problems in math, science, and engineering, submit approaches and hypotheses, and verify the work with a community of AI-powered enthusiasts. AI's biggest impact won't be personal productivity. It will be unlocking scientific breakthroughs that humans alone can't reach.

We automate the entire end-to-end prior-authorization process for private practices for cheaper, and more accurately than they're doing today.

The first AI data analyst that has its own computer. It sees and understands your docs, Slack, databases, data lakes, and codebase. Query, debug, and analyze right where your team works.

Iris observes how you handle your day - how you reply, decide, prioritize - and prepares the next set of actions. Our key insight: if you model real behavior, you can replicate judgment, not just tasks using personal agents and knowledge graphs. Iris knows what needs your attention across your accounts, pre-fills the actions, and you can simply swipe right to hand it off to your agent. We started with connecting calendars and emails. We launched four weeks ago. Over 1,200 people have downloaded Iris, 168 use it every day, and they’ve taken more than 36,000 actions so far growing 48% week over week. In the future, everyone will have a personal proxy running their digital life with near perfect accuracy. Iris is the first real version of that future.

Jarmin.ai is your 24/7 ML eng employee that you hire. Just talk to Jarmin like any other employee and Jarmin handles your AI/ML work from there. Completely hand over full initiatives or individual tasks. Jarmin’s founding team is from Meta SuperIntelligence Labs (Staff Engineers), Apple (Machine Learning Engineer), AWS (scaling infra), Lockheed-Martin (Research), and JPMorganChase (SWE) with experience building AI/ML and automating complex work of Researchers, Data Scientists, ML Engineers with AI.

item connects to all your customer tools, gathers and enriches context automatically, and becomes your company’s source of truth — one place where your team and your AI agents share the full picture to act autonomously. At the center is the Assistant — your sidekick for daily work. It can send follow-ups, research leads, or add deals with a simple prompt. No complex UI, drop-downs or fields, simply ask. For repeatable work, you build Agents that you can train like new hires, simply by writing documents that describe your processes. item Agents run business processes across sales, support, and account management autonomously.

We build AI that runs carrier operations. Lunavo is the AI assistant for carriers. It plugs directly into their existing toolstack, understands their processes, and monitors all incoming data and requests. Lunavo runs end-to-end backoffice operations, handling repetitive tasks, resolving issues autonomously, and escalating only what matters. Lunavo helps carriers scale operations without scaling headcount.

Logical is a desktop AI that acts as a proactive and largely promptless copilot, designed to reduce the friction of using AI for everyday tasks. It transfers context across apps, and allows taking action on many apps with just a few clicks. Logical can assist with drafting emails, writing docs, noting meetings and can even automatically detect action items. Need to prompt? Logical can understand intent in much fewer words than a regular chatbot. Plus, user data is never sent to Logical servers. Logical is the AI resurrection of Clippy, but actually good.

Sciloop is building an AI Co-Scientist that automates experimentation and analysis for machine learning researchers, allowing them to test ideas far faster than today’s tools allow. We are Bilal and Osman, International Physics Olympiad medalists and the only Pakistanis admitted to MIT in our respective years, with several years of hands-on ML research experience inside MIT CSAIL. We have built large-scale training pipelines, worked with terabyte-scale datasets, and seen the research bottleneck firsthand while contributing to scientific ML projects. We left MIT to solve this problem directly and are now building a system that can eventually accelerate scientific discovery itself. https://sciloop.dev

Aside listens to your sales calls and surfaces real-time answers pulled from your docs, HubSpot, or past calls. It's like pressing 𝚌𝚝𝚛𝚕+𝚟 on your company’s knowledge into every rep – so anyone can sound like your best rep. - 🔎 Shows answers from your docs, Slack, and past winning calls - 📝 Live coaching that catches what reps miss: Aside spots what reps skip during calls and guides every rep to apply your playbook - BANT, SPICED, or your own - not after, live. - 💬 Preload your cheatsheets as Live Cards: Turn your playbooks, FAQs, and notes into instant, in-call cards. - 🎓 Coaching feedback, remembered by AI: Aside reviews every call, gives feedback, and turns it into live suggestions for your next one - so you never repeat the same mistake.

Fastshot is a no-code mobile development platform. Our mission is to "Democratize mobile app creation with AI" Anyone can develop a mobile app from idea to App Stores within minutes just by chatting with AI.

Automate internal auditing (planning, testing, documenting) to comply better with financial regulations. Denki performs audit work with 99% software, 1% services: ✔️ Works on existing systems (e.g. Auditboard, Workiva, ERPs) ✔️ Automates Control processes (e.g. collects evidence, runs walkthrough interviews, tests) ✔️ Records every step for traceability (workpapers w/ full audit trace) Focused on SOX programs and financial regulations (SEC Rules etc.)

Bravi is building the AI operating system for home-services businesses, using AI-powered customer communication as the wedge. We replace the front office (calls, chats, follow-ups) with AI agents that never miss a lead, then layer an internal AI copilot that understands products, pricing, and technical documentation. We started with fenestration (shutters, windows, garage doors), a large, complex vertical with no modern software, before expanding to adjacent trades. Bravi is already live with leading installers and manufacturers across Europe and the US, turning missed demand into revenue.

Brickanta is building the AI-native operating system for construction, starting with the pre-construction workflows that determine the outcome of entire projects: bid analysis, cost estimation, and procurement. Our platform combines state-of-the-art AI with real project data, standards, and construction best practices. This enables construction, contracting, and real estate companies to identify gaps, risks and opportunities earlier, and to produce project and procurement documentation significantly faster and more efficiently.

Clodo is the planet's best people search. Used by GTM, Recruiting, Marketing, and Ops at AI Natives, B2Bs, and Fortune 500s in SaaS, Manufacturing/Industrials, BioTech, Healthcare, Fintech, Compliance, and more

Meet Meteor: a Chrome-alternative that can actually do your work for you. With agents getting better by the day (literally), we realize that it’s time to automate the boring, tedious work. We use your browser session to empower agents to act like your personal assistants (ex. book a calendar, find cheaper flights, buy clothes on amazon etc.) Some of Meteor’s features: - Chat with any page - Integrate with popular apps like Gmail, Google Calendar, Twitter etc. - Browser agent to autonomously navigate the web and perform tasks - More coming soon! We're excited to usher in a new era of browsing.

Epicenter is an ecosystem of open-source, local-first apps that share a memory. We store all your work—notes, transcripts, chat histories—in a single folder of plain text and SQLite. Every tool we build shares this memory: your text editor, personal assistant, etc.. It's open, tweakable, and yours. Grep it, open it in Obsidian, host it wherever you like. The choice is yours. Our vision is to build a personal workspace where you own your data, choose your own AI models, and replace siloed apps with open, interoperable alternatives. All while preserving authenticity and being free and open source. ❤️

Omnara brings Claude Code and Codex to your phone. Start a coding session on your desktop, then seamlessly hand off to mobile and keep building whether you're commuting, traveling, or away from your desk. Code in local or remote environments with full context preservation across devices. Plus, use voice to code hands-free by having natural conversations with Omnara to build, debug, and ship from anywhere.

April is a voice AI Executive assistant that manages your email and calendar, hands free. It’s built for busy individuals who need EAs but don’t have them.

SigmanticAI is building an AI-native hardware development assistant that automates the entire RTL design flow, from natural language to synthesizable HDL and testbenches, inside a seamless VSCode fork. Powered by fine-tuned Verilog LLMs, reinforcement learning, and real compiler feedback, SigmanticAI iteratively refines code until it compiles and passes synthesis, no matter how complex the design. It’s like the Cursor for HDL design. In addition to code generation, SigmanticAI can generate token-level annotations and onboarding documents to accelerate ramp-up for new engineers. With support for both cloud and on-prem deployment, it integrates with existing EDA tools to dramatically reduce debug time, improve collaboration, and accelerate hardware design across teams

Bond is an AI Chief of Staff that gives CEOs and busy executives real-time visibility into what’s happening across the company and tells them what to focus on. Saving execs 10+ hours a week.

Alkali is building the co-pilot for chemical process design. Spot design errors earlier, get the right equipment sooner, and build chemical projects faster.

Orchid is a proactive work agent that connects to your inbox and calendar, handles tasks autonomously, and surfaces only the decisions that need you.

Flott helps transport and logistics companies run leaner, smarter, and more profitable operations. Flott unifies everything transport and logistics teams need in a single, AI-powered control center—bringing planning, live tracking (gps, fuel, etc), invoicing, and payments into one place and delivering true end-to-end visibility. Flott’s AI agents act as an extension of fleet managers — automating repetitive tasks and optimizing workflows.This lets companies focus on what truly matters: growing the business.

Ovlo is a no-code AI platform for supply chain teams, building custom agents that automate critical workflows like demand forecasting, compliance validation, invoice reconciliation, and inventory optimization to eliminate manual errors and supercharge efficiency. As an AI layer connecting onto of your current tech stack, even email and Sheets, it creates streamlined end-to-end processes, empowering teams.

Truffle AI makes it easy for developers to integrate AI agents into any software application. We do this by exposing agents as simple APIs that can be called from anywhere. Developers have used Truffle to add customer support agents into WhatsApp and analytics agents into Slack.

Rebolt lets everyone in the company build apps, and agents by speaking with AI. Integrated with your company tools, data and authentication. Replacing no-code tools, bloated SaaS and complex spreadsheets, for automating all the boring work.

TamLabs is an applied research lab redesigning how knowledge work gets done.

Paratus Health is the AI operations layer for outpatient clinics. We build autonomous agents that don’t just assist staff - they replace them, fully handling front desk calls, patient intake, insurance verification, documentation, and billing prep. Everything is deeply integrated into EHRs like Epic and Athena, eliminating the need for fragmented tools and manual work. No toggling between systems. No busywork. Just one intelligent system running your clinical operations - faster, smarter, and more profitably than ever before.

G LNK is an AI-powered platform simplifying how healthcare companies connect with the relevant medical professionals. Our proprietary matching and ranking models instantly identify the most qualified experts, accelerating drug development and commercialization. Designed with compliance at its core, G LNK ensures every connection meets strict regulatory and ethical standards—empowering companies to innovate faster with confidence.

assistant-ui helps frontend developers add AI chat to their apps. Our product is used by several dozen companies, like LangChain, Stack AI, Browser Use, and Athena Intelligence. We're building an open source Typescript/React library and a backend as a service, with first class integrations into popular agent frameworks like LangGraph and Vercel AI SDK.

Altrina automates SOPs to give humans back their time to do what matters. We have already significantly improved organizational efficiency for local governments, law offices, insurance brokers, consulting firms, and hedge funds. Formerly General Agency/Tessa AI

jo is a personal AI that runs on your Mac and a private cloud machine we host for you. It knows your life, improves itself autonomously, chats via Telegram and WhatsApp, and never shares your data. Less "chatbot" and more "a second brain that does things."

Edexia is an AI Teacher Assistant for grading essays. It can be trained and controlled by the teacher and can grade assignments from any curriculum, year level, subject, or format. Learning like a teacher, Edexia visually breaks down its understanding of the rubric, and updates this as a teacher corrects it. Our vision is to transform education by facilitating AI’s safe and effective integration across all institutions and applications. Not using AI to replace teachers but rather to empower them—providing them with all the time and resources they need to develop their students.

Vortexify AI is a platform for building fully operational AI workflows tailored to supply chain operations. Deploy specialized, task-specific AI bots in days — not weeks. Our platform streamlines the creation of AI bots that can analyze millions of data rows, manage complex, long-horizon processes, and collaborate seamlessly with humans in the loop. Each AI bot comes equipped with custom tools maintained through AI-powered code editors directly within the Vortexify platform. Development teams can instantly generate dashboards, data pipelines, machine learning models, and custom functions — all contextualized to business goals and data requirements. Bots can operate in Co-pilot or Agent (autonomous) mode. They can be scheduled or triggered by real-time alerts and are governed by robust, natural language-generated guardrail templates that ensure safety, compliance, and reliability.

Endstack is a desktop OS optimized for humans and agents running in the cloud. Your desktop is powered by endOS, giving you a real desktop workspace in the browser backed by Linux in the cloud. Files, notes, browser tabs, native apps, terminals, and all your agents in one beautiful, familiar, interface. You get a powerful agent running 24/7, integrated at the system level into endOS that you can also reach via Slack, email, or SMS. Endstack desktops are also natively multiplayer, allowing for realtime collaboration with teammates.

Email sucks. It takes forever to go through, and hiring an assistant is costly and invasive. Friday is building the assistant that learns how to predict the action that you will take on your emails, and does it for you. Today's email products try to help you go through your emails a little faster, but if you have to get through 1000 emails, those products doesn't do much for you. The reality is, most of the emails you get don't require you to personally look at them. Friday completely eliminates the need to check those emails, and handles them all at once for you, immediately. Friday is here to file away spam, sift through newsletters for important tidbits, text you important notifications, and reply to mundane emails, so that no matter how many thousands of emails are in your inbox, you'll just be left with the few emails that actually require your personal touch. Getting this right is difficult, so everyone else settles with trying to help you go through your email twice as fast. If you want to go 100x as fast, you shouldn't spend even a second on useless emails. Friday gets this right, bringing the elite experience of having a professional assistant to the entire world.

Orchestrate an army of coding agents from one dashboard. Ship entire sprints in parallel.

The AI-native document editor for long-form content. Create, edit and review with full end-to-end traceability and full searchability of your source documents. Perfect for regulatory, compliance and legal professionals.

Sandra AI is building the AI operating system for car dealerships, replacing clumsy legacy software with an AI-native, automation-driven platform. Founded by 3 McKinsey, HEC & MIT alumni who met 10 years ago at Ecole Polytechnique, the company’s AI agents already automates all customer interactions across calls & messages, and increasingly run dealership operations by automating sales and aftersales workflows end-to-end. This operational footprint naturally extends into a proprietary software layer that unifies billing, scheduling, inventory, and CRM into a single dealership OS.

Random Labs is building Slate. Slate is a coding agent designed to work with you for long hours on hard problems.

Consumers miss out on $70B+ every year because they're busy and unaware, and that money is sitting in their email inbox. So, we automated reading email receipts and claiming the money they're entitled to, offering a service to which you can sign up once, do (literally) nothing, and earn $. Where is this money coming from? - Retailers: When the price of clothes or furniture you've already bought drops, you're entitled to a refund for the difference - Airlines: When a flight you've booked gets delayed or canceled, you're entitled to a cash compensation. - Enterprises: When a class-action lawsuit is filed against a company you engage with, you're entitled to money. - And many more, that even the government holds some of your unclaimed funds. Today, the dream of one service that automatically claims the money you deserve when you shop, fly,... and live is (finally) possible. We started with automating refunds in the shopping industry and have secured $8,000 in refunds to our users, growing 233% MoM. With AI, we've been able to repurpose that same automation to tackle refunds in the flight industry and the class-action lawsuit landscape. Why us? (1) We're obsessed with reclaiming what's rightfully yours: Kamal and Anthony grew up in Lebanon, where people's money was unfairly taken away. (2) Weijie was the lead infra engineer for Wish's recommendation system, the feature that fueled their IPO. Our combined experience includes Apple, Addepar, Bolt, Wish, and StackAdapt. And we're all working towards one goal: move those billions of dollars where they belong.

Orca lets you create and edit Minecraft servers, mods, and datapacks directly in your browser using an AI coding assistant, no setup required.

ProhostAI is building an AI Property Manager for short-term rental hosts on Airbnb and other platforms. Our team consists of an ex-Airbnb Staff Data Scientist and Dropbox Sr Software Engineer who are also Superhosts with 9 properties worth $15M making $1.5M/yr.

MinusX is a chrome extension that adds a side chat to your analytics apps (Jupyter, Metabase, Grafana, Tableau, etc). Given an instruction, our agent operates your apps - by clicking & typing, just like you do - to analyze data and answer queries. We believe an AI Data Scientist is a scientist, not yet-another-new-analytics-platform. MinusX interoperates with you in tools you already love and use, and as a matter of philosophy, gets out of the way.

Zuni is a Chrome extension that gives you AI capabilities in the sidebar of your browser. It can use what it sees on any of your tabs as context, and proactively helps you draft messages and emails.

An OpenClaw Framwork that builds an AI Workforce paired with an in-built CRM, that lives in your communication channels, is online forever, knows your everything about your business. and does the tasks on your behalf only so you can click "Approve" every morning. Build you own AI employees today... - Lead intake via Voice / SMS / Email and then updating the Contact / Matter / Case in the CRM. - Connects with Gmail / Outlook for AI to write replies (in draft for you to review) all ready to send, for every email that deserves your reply, so you don't spend time writing emails anymore. - Handles outbound sales completely, scrapes all the leads there possibly are on the internet, phone books, data brokers, and contacts customers, chats back and forth with them at scale, infinitely, parallely all at once. - Writes daily/weekly/monthly briefings and reports based on all the new context there is on the CRM every day/week/month. It finds out insights you possibly couldn't have found by looking at it all manually. - Customer Research AI agents: find powerful POCs of a company, check through your LinkedIn connection tree to find out how far apart in mutual connections you are from them, research their background, and send out intro texts / emails / call agents to connect you with the POC. and so much more. Contact us for enterprise needs.

Domu automates debt-collection calls, texts, and emails for financial services and healthcare. We work with some of the largest financial institutions in the world and win by doing what nobody else is willing to do. We are hiring :)